Scientific Reports of the Milan School of Medicine 2022, 1

SIGNIFICANT INCREASE OF MORTALITY IN >80 ANTI-SARS-COV VACCINATED PEOPLE COMPARED TO UNVACCINATED AND 12-39 PEOPLE AND THE ANTI-COVID 19 VACCINES GENOTOXICITY

Raw data from the Italian “ EPICENTRO Istituto Superiore di Sanita’” ( October 9-November 10), depict a lethality of unvaccinated people N = 162 and n= 214 in vaccinated people with anti-SARS-COV vaccines. The type of vaccine is unspecified but presumably is mRNA.

Epidemiological elaboration of data shows in oldest people > 80 after two doses of vaccines < 6 months a significant increase of lethality risk compared with unvaccinated (OR 1.59-IC q.1.2356 to 2.0587 P=0.0003 (table 1)  and a non-significant increase of lethality in the vaccinated range 12-39: OR 1.2-CI 0.1691-8-8229 (TABLE 2)  (raw data are small).

                                                    Table 1

 

                                                              Table 2    

 

Odds ratio	1.2074
95 % CI:	0.1691 to 8.6229
z statistic	0.188
Significance level	P = 0.8510

                    After the first dose, there is  a tendency to an increased risk of lethality in the vaccinated compared with unvaccinated in the range 60-79 close to 0,5 significance: OR 1.23 ( CI 0.5686 to 2.6962-P =0,5904)  (Table 3)

 In > 80 the lethality risk of vaccinated people is less than the full cycle of vaccination. (OR = 1.07 ,CI 0.5397 to 2.1330P = 0.8409 (Table 4)

 

          Table 3                 

Odds ratio	1.2382
95 % CI:	0.5686 to 2.6962
z statistic	0.538
Significance level	P = 0.5904

         Risk of the lethality of 60-79 vaccinated people after 1 dose of vaccine compared to unvaccinated                           

    

Odds ratio	1.0729
95 % CI:	0.5397 to 2.1330
z statistic	0.201
Significance level	P = 0.8409

Risk of the lethality of >80 0F vaccinated people after 1 dose of vaccine compared to unvaccinated

The increased risk of mortality in>80 could be explained by a direct effect of mRNA vaccines inducing genotoxicity from the micro-RNA silencing of the innate immunity, caused by the vaccines' n1-Methil pseudouridine binding with micro RNA and immunosenescence.
Genotoxicity of mRNA and vectorial vaccines is well documented and exposes people to severe adverse effects like tumors, self immunity,psycho-neurobehavioral disorders, inhibition of natural immunity. ( 1 ,2, 3, 4, 5, 6, 7,8 )
There is also an actual incoherence between scientific data and the apparent successful general induction of lethality reduction by vaccines.
mRNA vaccines do not induce CD8+ synthesis but only activate APC to produce an IFN gamma-induced CD4-TH1 increase in local lymph nods close to the inoculation site, not joining lungs and activating residents memory cells responsible for preventing respiratory infections. Moreover, they do not induce immunity in the mucous membranes of the pharynx and upper respiratory ways because IGAs are absent. This evidence presents the political decision for the Green Pass to protect from contagion without any scientific basis. Anti-SARS COV to date available loss their efficacy in a short time because of the "Original antigenic sin". (9, 10)
The Italian population has been inundated with a pro-vax campaign by the Italian central health and regional governments supported by media-inducing vaccination and mediatic virologists. There is a pandemic of ideological and false statements, as it occurred with a vaccination campaign for adolescents and young people not at risk of COVID-19, that if rarely infected, they are asymptomatic and with a ratio of cases/fatality to zero or almost. Roberto Speranza, the Italian Health Minister, declared "The full agreement of all scientists" about the need for vaccination in all ages". Franco Locatelli, the director of the Anti SARS-COV Italian Technical, stated on August 20 the inexistence of adverse effects for adolescents to induce parents' authorization after the news of healthy adolescents' deaths after vaccination from Italy and USA and signalization of adverse effects by the USA CDC, also in contrast with health policy of countries like the UK and the WHO opposite suggestions.
There is an emergency to block the delusional idea to submit to vaccination 5-12 children and to block adolescents' and > 80 older people's vaccination. Children and adolescents are not at risk of COVID-19 . are rarely infected and almost asymptomatics, and in such a way, they contribute to realizing the "herd immunity." (11). Asymptomatic people do not transmit infection as symptomatic do. (12,13,14)
There is an urgent need for a full shift of public health policy that must be primarily addressed to older people with comorbidities at risk of lethality. 92 % of lethality  associated with COVID-19 is determined by comorbidities. Primary and secondary prevention must be established by adopting the Person-Centered Prevention paradigm inspired by the Person-Centered Medicine change of the medical science paradigm. (15, 16, 17, 18 ,19 ,20 , 21 ,22 ) This change, unknown by most public health administrators for scientific and epistemological ignorance, leads to induce a metabolic and immunostimulant shield through the institution of the "Antiviral allostasis and preventive immunostimulation" able to neutralize the Sars-Cov 2 binding to receptors, entry, replication, and to induce cross-prevention against non-communicable diseases like cancer. (23, 24)

References

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2 Lockhart J, Canfield J, Mong EF, Vanwye J, Rotary-Jain H. Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019;14:339-350. doi:10.1016/j.omtn.2018.12.00

3  Doerfler W. Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. DOI: 10.1016/j.virusres.2021.198466. Epub 2021 Jun 1. PMID: 34087261; PMCID: PMC8168329

 4 Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009;30:80-91.

5 Schratt G. microRNAs at the synapse. Nat Rev Neurosci. 2009 Dec;10(12):842-9. DOI: 10.1038/nrn2763. Epub 2009 Nov 4. PMID: 19888283.

6 Raisch J, Darfeuille-Michaud A, Nguyen HT. Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol. 2013;19(20):2985-2996. doi:10.3748/wjg.v19.i20.2985

7 Strains M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci USA. 2009;106:2735-2740

8 ShaohongHuang, ShaoningLuo, ChulianGong, LiminLiang, YiXiao MinganL, JinyuanHe MTTL3 upregulates microRNA-1246 to promote occurrence and progression of NSCLC via targeting pateRNAlly expressed gene 3Datamolecular Therapy - Nucleic Acids, ISSN: 2162-2531, Vol: 24, : 542-553. 2021

9 Federico M Biological and immune responses to current anti‐SARS‐ CoV‐2 mRNA vaccines beyond anti‐Spike antibody production   paper submitted to Medrix

10 Federico M The conundrum of current anti-SARS-CoV-2 vaccines. Cytokine & Growth Factor Reviews.2021;60:45-61.

11  Erika Molteni, H. Sudre, Liane S. Canas, Sunil S. Bhopal, et al. Illness duration and symptom profile in a large cohort of symptomatic UK school-aged children tested for SARS-CoV-2. Lancet; 2021 internet   file:///C:/Users/Utente/Documents/UA/ricerca/Corona%202/Illness%20duration%20and%20symptom%20profile%20in%20symptomatic%20UK%20school-aged%20children%20tested%20for%20SARS-CoV-2%20-%20The%20Lancet%20Child%20&%20Adolescent%20Health.html

12 Byambasuren O.Cardona M.Bell K.et al. Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis. J Assoc Med Microbiol Infect Disease Canada (JAMMI). 2020; 4: 223-234

13 Madewell ZJ, Yang Y, Longini IM, et al. Household Transmission of SARS-CoV-2. A systematic review and meta-analysis. JAMA Netw Open 2020;3(12):e2031756.doi: 10.1001/jamanetworkopen.2020.31756. 12.18.2  

14 Gao M, Yang L, Chen X, et al. A study on infectivity of asymptomatic SARS-CoV-2 carriers. Respir Med.     2020;169:106026. doi:10.1016/j.rmed.2020.106026

15 Brera G.R. The manifesto of Person-Centered Medicine. Medicine, Mind Adolescence,1999; Vol. XIV, n. 1-2:3-7

16 Brera G.R. . Person-centered Medicine and Medical Education in the Third Millennium (with the introduction of Iosef Seifert The seven aims of Medicine it.) Roma- Pisa: IEPI ;2001 (Italian)

17 Mezzich E.J. The Geneva Conferences and the emergence of the International Network for Person-centered Medicine. Journal of evaluation of Clinical Practice 2011;17(2):333-33

18 Brera G.R. Person-centered Medicine: Theory, Teaching, Research. Int.J.Pers. Cent.Med 2011; 1 (1):69-

19 Brera G.R   et al. Reliability and validity of Person-centered Medicine Clinical Method for a Person and People-Centered Care: a survey on 144 clinical reports of physicians prepared to apply Person-centered Clinical Method to adolescents from the Academic Year 1997 to 2002 at the Milan School of Medicine of the University Ambrosiana. Proceedings of the Vth Geneva Conference on Person-centered Medicine. 2012 April 30-May 2 Geneva, Person-centered Medicine International Network 2012.   DOI 10.13140/RG.2.1.4699.0568  

20 Brera G.R. The Person-centered Health Paradigm and its impact on health sciences.(Internet) Research Gate 2015 DOI:10.13140/RG 2.1.2594.1925 2015-05-21 T 15:42:05 UTC. Available from

https://www.researchgate.net/publication/277010325

21 WHO Person-centered Medicine and Medical Education. (internet) Geneva: WHO Symposium; 4 May 2011. WHO Available from

http://www.unambro.it/html/pdf/All_Symposium_Education_People_Centred_4May2011.pdf

22 Brera, G.R Person-Centered Medicine, and Person-Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021

23 Brera G.R Sars-Cov-2 allostasis and the people and person-centered prevention. A new prevention strategy based on a people metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Università Ambrosiana , 2021. ISBN: 9798530093906

24 Brera G.R . SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The Sars-Cov 2- induced immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation - How to induce zero risk for covid-19. Milan: Ambrosiana University: 2021 ISBN

 

* Milan School of Medcine, World Health Committee, Comitato Sanitario Nazionale
** School of Medicine of the Minnaeapolis University, Scuola Medica di Milano,World Health Committee,Comitato Sanitario Mazionale

 

 

 

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